The Ultimate Guide To https://www.ceesdekker.net

The Ultimate Guide To https://www.ceesdekker.net

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Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:

Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular varieties with recombination function.

, Groningen scientists existing the results in their endeavours to help make labs a lot more sustainable and supply guidelines for other labs. 

Since 2000, Dekker has shifted the principle aim of his function toward biophysics where he scientific studies the Houses of single biomolecules and cells using the instruments of nanotechnology. This alteration of field was driven by his fascination for that extraordinary functioning of biological molecular structures, and also via the long-term viewpoint that lots of attention-grabbing discoveries can be expected On this discipline.[five] Present-day strains of research in his biophysics group are within the areas of:[6]

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review in the dynamics DNA supercoils and the invention of supercoil hopping

Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,

You're a Christian. If you might make such a artificial cell, would you be a person phase closer to God, or would the position of God have diminished relatively all over again?

Atomic pressure microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative vogue

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There was one particular challenge nevertheless — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been essentially not these types of terrific conductors, which was rather disappointing. We Therefore broadened our see to try to discover a lot more promising molecules.

Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of your pore is highlighted in pink, plus a 3D rendering in the motion of the DNA rod is exhibited.

2006, initially demonstration of molecular sorting in a lab over a chip using biomotors; discovery of nanobubbles in strong-condition nanopores; and to start with estimate of electrokinetic Power conversion in the nanofluidic channel

Visualization of unstained DNA cees dekker nanostructures with Sophisticated in-emphasis transmission electron microscopy approaches

 Lastly, I will briefly sketch a few of our Concepts to examine the setting up of artificial cells, specifically our first actions to establish synthetic cell division.